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CZS 5.2 Cerebrale schimmelinfecties – Aspergillus spp

Advices

≥ 18 years

Indications: Cerebrale aspergillose met onbekende azool-gevoeligheid

Priority Medication Remarks
Priority:
1st choice
Medication:

voriconazol iv 4mg/kg 2dd

+

amfotericine B liposomaal (Ambisome) iv 5mg/kg 1dd

Remarks:

Voriconazol eerst opladen: dag 1 6mg/kg 2dd

Priority:
2nd choice
Medication:

amfotericine B liposomaal (Ambisome) iv 5mg/kg 1dd

≥ 18 years

Indications: Cerebrale aspergillose met aangetoonde azool-resistentie

Priority Medication Remarks
Medication:

amfotericine B liposomaal (Ambisome) iv 5mg/kg 1dd

≥ 18 years

Indications: Cerebrale aspergillose met aangetoonde azool-gevoeligheid

Priority Medication Remarks
Priority:
1st choice
Medication:

voriconazol iv 4mg/kg 2dd

Remarks:

Voriconazol eerst opladen: dag 1 6mg/kg 2dd

≥ 18 years

Indications: Cerebrale aspergillose met aangetoonde azool-gevoeligheid

Priority Medication Remarks
Priority:
2nd choice
Medication:

isavuconazol iv loading dose 200mg, 3dd 2 days

followed by

isavuconazol iv 200mg 1dd

General comments

Voor spiegelbealing voriconazol zie "Overig --> spiegelcontrole"

Sources

TDM Alert
Antimicrobial resources

The following antimicrobial agents have been used in these recommendations:

External antimicrobial resources
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Metadata

Swab vid: G-444453.3
Updated: 04/22/2021 - 11:27
Status: Published