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LWI 5.1 Pneumonie - (fungaal) Pneumocystis jirovecii (PJP)

Advices

≥ 18 years

Indications: milde tot matige PJP

Priority Medication Remarks
Priority:
1st choice
Medication:

cotrimoxazol (trimethoprim +sulfamethoxazol) 1600/320mg 3dd 21 days

Remarks:

indien milde klachten per os behandelen

Bij gewicht <50kg: 1440 mg iv, 3dd 21dagen

Priority:
2nd choice
Medication:

clindamycine iv 600mg 3dd 21 days

+

primaquine po 30mg 1dd 21 days

Remarks:

bij overgevoeligheid cotrimoxazol

Primaquine niet toedienen bij glucose-6-fosfaat dehydrogenasedeficiëntie

Priority:
2nd choice
Medication:

dapsone po 100mg 1dd 21 days

+

trimethoprim po 300mg 1dd 21 days

Remarks:

bij overgevoeligheid cotrimoxazol

Priority:
2nd choice
Medication:

atovaquon po 750mg 2dd 21 days

Remarks:

suspensie, innemen met voedsel

≥ 18 years

Indications: matige tot ernstige PJP

Priority Medication Remarks
Priority:
1st choice
Medication:

cotrimoxazol (trimethoprim +sulfamethoxazol) iv 1920mg 3dd 21 days

Priority:
2nd choice
Medication:

clindamycine iv 600mg 3dd 21 days

+

primaquine po 30mg 1dd 21 days

Remarks:

Bij overgevoeligheid cotrimoxazol

 

Of clindamycine 3dd 600 mg po

Priority:
2nd choice
Medication:

pentamidine iv 4mg/kg 1dd 21 days

General comments

Bij pO2 < 9 kPa toevoegen prednison:

  • dag 1-5 2 dd 40 mg;  
  • dag 6-10 2 dd 20 mg;
  • dag 11-14 1 dd 20 mg.         

 

Na behandeling secundaire profylaxe.  

Sources

Antimicrobial resources

The following antimicrobial agents have been used in these recommendations:

External antimicrobial resources
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Metadata

Swab vid: G-142945.11
Updated: 02/10/2023 - 16:08
Status: Published