Radboud UMC

CAR 3.1 Mediastinitis

Advices

≥ 18 years

Indications: Perforatie oesofagus/hoofd-halsinfecties
Priority	Medication	Remarks
	Medication: amoxicilline + clavulaanzuur iv 1000/100mg 6dd	Remarks: Community-acquired
	Medication: piperacilline/tazobactam iv continuous per 24 hours minimum 4 weeks or piperacilline/tazobactam iv 4500mg 4dd minimum 4 weeks	Remarks: Nosocomiaal Dosering bij continue infusie: Piperacilline/tazobactam eerst opladen met 4000/500mg in 30 minuten, daarna 16000/2000 mg continu per 24 uur.

≥ 18 years

Indications: Postoperatief na sternotomie
Priority	Medication	Remarks
	Medication: cefuroxim iv 1500mg 3dd minimum 6 weeks	Remarks: Geen klep- of vaatprothese in situ.
	Medication: cefuroxim iv 1500mg 3dd minimum 6 weeks + vancomycine iv minimum 6 weeks	Remarks: Klep- of vaatprothese in situ. Voor dosering vancomycine zie vancomycine \| Radboud UMC

Sources

Baddour LM et al. Circulation 2015;132:1435-86.

TDM Alert

Vancomycine

Antimicrobial resources

The following antimicrobial agents have been used in these recommendations:

External antimicrobial resources

Menu position

Heart and thorax

Metadata

Swab vid: G-143033.18
Updated: 01/31/2025 - 14:51
Status: Published